Abstract
We previously have reported that hepatitis C virus (HCV) infection and heavy alcohol consumption are risk factors for the development of hepatocellular carcinoma (HCC) in patients with cirrhosis. Genotype II (1b) HCV (HCV-II) has frequently been reported in patients with HCC. The aim of this study was to determine statistically whether HCV infection and alcohol consumption are related to the mortality rate for HCC or liver cirrhosis among patients in various countries. Statistical analysis was based on 11 countries (Japan, U.S.A., France, Italy, Brazil, Canada, U.K., Germany, Finland, Spain, and Sweden), for which the rate of anti-HCV positivity or the percentage of HCV-II in patients with noncancerous chronic liver disease has been reported in papers and abstracts. The mortality rate for HCC was found to be related significantly to the rate of anti-HCV and HCV-II positivity, while the mortality rate for liver cirrhosis was related to alcohol consumption.
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