Clopidogrel pharmacogenetics of east, south and other Asian populations

Abstract

have also shown that Malay–Singaporean subjects, who are Asians of Austronesian descent, and Indian– Singaporean subjects, who are of South Asian descent, have an increased prevalence of the *2 LOF polymorphism when compared with Caucasian subjects. The homozygous *2 genotype, which is associated with the highest level of on-treatment platelet reactivity and is present in 2–3% of the Caucasians, was present in 6% of the Chinese, 9% of the Malays, and 13% of the Indians in our study. The prevalence of *2 polymorphisms among the Indian subjects in our study was higher than that observed in Caucasian populations but similar to other studies on Indian subjects from the Indian subcontinent. 5