Abstract
A cDNA of rat brain encoding the GABA A receptor α 4 subunit has been cloned. Recombinant receptors composed of α 4, β 2 and γ 2 subunits bind with high affinity the GABA agonist [ 3H]muscimol and the benzodiazepine ‘alcohol antagonist’ [ 3H]Ro 15-4513, but fail to bind benzodiazepine agonists. The α 4 subunit is expressed mainly in the thalamus, as assessed by in situ hybridization histochemistry, and may participate in a major population of thalamic GABA A receptors. The α 4 mRNA is found at lower levels in cortex and caudate putamen, and is rare in cerebellum.
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