Abstract
We have cloned the rat angiotensin II receptor type 2 (AT 2) gene, whose physiological function remains unclear. Sequence analysis indicated that exons 1 and 2 exist in the 5′-untranslated region and the initiation codon ATG is located in exon 3. The 1.6-kb genomic fragment at positions − 1567 to + 26 relative to the putative transcription start site was found to contain a functional promoter region using transient chloramphenicol acetyltransferase assay. This is the first report demonstrating the nucleotide sequence of the promoter region of this gene.
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