Abstract
Uninfected cells contain DNA sequences related to the genetic information of infectious retroviruses. In addition to these so-called ‘endogenous proviruses’, certain vertebrate cells contain gene families that are distinguished by several ‘retrovirus-like’ properties but are, nevertheless, unrelated to retroviruses (i.e., there is no nucleic acid homology with known retrovirus). The possible genetic origin of ‘retrovirus-like’ gene families and their potential biological significance are discussed. These issues were experimentally approached in our laboratory with a particular endogenous ‘retrovirus-like’ family, namely, the murine VL30 family. VL30 DNA elements are ubiquitous in murine cells where multiple copies are dispersed throughout the genome. The 30S RNA that is constitutively transcribed from these genes can be efficiently packaged in C-type virions and is capable of subsequent transmission to other cells via pseudovirion infection.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
