Abstract

The complete amino acid sequence of a new member of the TGF-β superfamily has been determined through initial degenerate PCR, subsequent cloning and nucleotide sequencing of the human cDNA. Amino acid homology comparison among members of this superfamily suggests it to be a new member of the activin/inhibin subgroup. The proposed mature part of the precursor shows 53 % amino acid identity to the activin βB and 51 % identity to the activin βA chain whereas βA and βB show an identity of 64 % to each other.

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