Abstract
We have cloned a cDNA encoding rabbit α 1d adrenoceptor from the rabbit liver cDNA library. The deduced amino-acid sequence of this clone encodes a protein of 576 amino acids that shows strong sequence homology to previously cloned human, rat and mouse α 1d adrenoceptors. The pharmacological radioligand binding properties of this clone expressed in COS-7 cells were similar to those of rat α 1d-adrenoceptors. Competitive RT/PCR assays revealed wide tissue distribution of the α 1d adrenoceptor mRNA in rabbit, especially abundant in vas deferens, aorta, prostate and cerebral cortex.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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