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Abstract
A recombinant-phage library of rabbit genomic DNA was screened for immunoglobulin VA genes. Two functional genes, Vλ2 and Vλ3, which are separated by 1.6kb were isolated and sequenced. Both are accompanied by signals required for transcription-translation and the recombination with Jλ genes. The two genes, which are 95 % similar in their framework regions, may be the parents of several cDNAs encoding VA regions. Rabbit Vλ-region diversity is likely to be generated by somatic mutation and V-J junction flexibility. Two cDNA clones encoding λ-light chains may have arisen by gene conversion, exchanging the complementarity-determining regions, CDR3s, of the Vλ2 and Vλ3 genes.
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