Cloning and expression profile of mouse and human genes, Rnf11/ RNF11, encoding a novel RING-H2 finger protein

Abstract

The RING finger (C 3HC 4-type zinc finger) is a variant zinc finger motif presents in a new family of proteins. A new member of the RING finger family was identified and its cDNA structures were determined in human and mouse. The predicted protein consisting of a 144 amino acid residues is very conservative between the two species and contains a canonical RING-H2 finger motif (C 3H 2C 2) at the carboxyl-terminal region. The genes were designated as RNF11/ Rnf11 for RING finger protein 11. A single 2.4-kb transcript of mouse Rnf11 was ubiquitously expressed in various fetal and adult mouse tissues by the Northern blot analysis. The human RNF11 gene was mapped on chromosome 1p31–p32 region, where frequent alterations have been observed in T-cell acute lymphoblastic leukemia.