Abstract
Human pregnancy-specific β 1-glycoproteins (PSGs) are a group of closely related placental glycoproteins and members of the immunoglobulin superfamily. To study possible functional roles of PSG, three type I cDNA ciones which encode PSG in a N-A1-A2-B2-C domain arrangement have been characterized in this laboratory. Now, we report the cloning of a type II cDNA (PSG9) which is 1512 bp and encodes a PSG of 332 amino acids in a N-A1-B2-C domain arrangement. In vitro expression experiments demonstrate that PSG9 encodes a 36 kDa nonglycosylated protein which is processed to a glycosylated protein of 46 kDa. Ribonuclease protection analyses show that PSG mRNAs that share sequence similarity with the PSG9 transcript are expressed in both human placenta and placental fibroblasts.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
