Abstract
Clonidine (10–30 μg/kg i.v.) caused dose-dependent reductions in blood pressure and heart rate of chloralose-anaesthetized cats pretreated with propranolol, and enhanced norepinephrine-induced reflex bradycardia. Bilateral lesions of the nucleus of the solitary tract prevented reflex bradycardia caused by norepinephrine and the bradycardia caused by clonidine but was without effect on the hypotension induced by clonidine. These results suggest that clonidine causes bradycardia but not hypotension as a result of a long-lasting central activation of baroreceptors.
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