Abstract
Clonidine is used by pediatricians and child psychiatrists for tics, Tourette's syndrome, and attention deficit disorder with hyperactivity (ADHD) with aggressive behavior. However, recent evidence of sudden death and cardiac toxicity associated with clonidine raises concern about the widespread use of this medication. There are three unpublished cases where the combination of clonidine and methylphenidate has been associated with unexplained sudden death in children ages 7,8, and 9 years (Frenia M.L., personal communication, September 21, 1995, Drug Surveillance and Information, Boehringer Ingelheim Pharmaceuticals).
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