Abstract
The fate of individual primitive hemopoietic stem cells is studied by retroviral gene transfer technique. Tens of small hemopoietic clones with a lifespan no longer than 1 month simultaneously function throughout life in lethally irradiated mice reconstituted with bone marrow cells. The disappearing clones are not detected again, which confirms the clonal succession. The number of primitive hemopoietic stem cells in mouse bone marrow has been directly estimated: 1 per 8000 hemopoietic cells, or 30×103 per mouse, which is at least ten times higher than expected.
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