Abstract
BackgroundAcinetobacter baumannii is a notorious opportunistic pathogen mainly associated with hospital-acquired infections. Studies on the clonal relatedness of isolates could lay the foundation for effective infection control. A snapshot study was performed to investigate the clonal relatedness of A. baumannii clinical isolates in our local settings.ResultsAmong 82 non-repetitive Acinetobacter spp. clinical isolates that were recovered during a period of four days in 13 hospitals in Sichuan, Southwest China, 67 isolates were identified as A. baumannii. Half of the 67 A. baumannii isolates were non-susceptible to carbapenems. blaOXA-23 was the only acquired carbapenemase gene detected, present in 40 isolates including five carbapenem-susceptible ones. The isolates belonged to 62 pulsotypes determined by PFGE and 31 sequence types (ST) by multi-locus sequence typing. Forty-three isolates belonged to the globally-disseminated clonal complex 92, among which ST75, ST92 and ST208 were the most common sequence types.ConclusionsClinical isolates of A. baumannii were diverse in clonality in this snapshot study. However, most of the isolates belonged to the globally-distributed clonal complex CC92. ST75, ST92 and ST208 were the most common types in our region. In particular, ST208 might be an emerging lineage carrying blaOXA-23.
Highlights
Acinetobacter baumannii is a notorious opportunistic pathogen mainly associated with hospitalacquired infections
Among 82 non-repetitive isolates that were recovered from clinical specimens from June 22 to June 25, 2011 in 13 hospitals in Sichuan and were putatively identified as A. baumannii by automated microbiology systems, 67 isolates were validated to be A. baumannii
As for the clinical significance, A. baumannii isolates were considered as either colonizers (55.2%) or pathogens (44.8%) causing clinical infections
Summary
Acinetobacter baumannii is a notorious opportunistic pathogen mainly associated with hospitalacquired infections. Studies on the clonal relatedness of isolates could lay the foundation for effective infection control. Investigation on the clonal relatedness of A. baumannii in local settings could generate useful data to understand the local epidemiology of this opportunistic pathogen and lay a foundation for an effective infection control program. For hospitals in Sichuan, Southwest China, A. baumannii was a huge problem as it was the most common bacterial species associated with HAIs and accounted for 17.3% of putative pathogens causing HAIs in a point prevalence survey [3]. A snapshot study was performed to investigate the clonal relatedness of A. baumannii clinical isolates in our local settings
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