Abstract
AbstractThe clinical courses of three patients with adult-onset diabetes mellitus who experienced perturbations in glucose control after exposure to two antidepressants are presented. Also explored are hypotheses on the mechanisms behind these changes relating them to serotonergic, adrenergic, and cholinergic neuronal transmission and synaptic concentrations. Observations include that chronic use of clomipramine might be related to hyperglycemia in patients with adult-onset diabetes mellitus. Further, acute and chronic use of fluoxetine in such patients might be linked to improved control of glucose. Finally, discontinuation of fluoxetine therapy might also be related to hyperglycemia in patients predisposed to adult-onset diabetes.
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