Abstract
To evaluate the efficacy of the stair-step protocol using clomiphene citrate (CC) and to assess the uterine and systemic side effects in patients with polycystic ovary syndrome (PCOS). A total of 60 PCOS patients who failed to respond to 50mg/day for 5days of CC treatment within the cycle were randomly allocated to the control (traditional protocol) and study (stair-step protocol) groups. In the stair-step protocol,patients were treated with CC 50mg/day for 5days and then in nonresponsive patients, the dosage was increased to 100mg/day for 5days in the same cycle. Patients who failed the 50mg/day CC treatment in the previous cycle were stimulated with 100mg/day CC and were accepted as the control group. Ovulation and pregnancy rates, duration of treatment and uterine and systemic side effects were evaluated. Ovulation and pregnancy rates were similar between the stair-step and the control group (43.3 vs. 33.3%, respectively) (16.7 vs. 10%, respectively). The duration of treatment was significantly shorter in stair-step compared to traditional protocol (20.5±2.0 vs. 48.6±2.4days, respectively). There were no significant differences in the systemic side effects between the groups. Uterine side effects were evaluated with endometrial thickness and uterine artery Doppler ultrasound; no significant differences were observed in stair-step compared to traditional protocol. The stair-step protocol was determined to have a significantly shorter treatment period without any detrimental effect on the ovulation and pregnancy rates.
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