Abstract
In Reply.— I. Erkul, H. Yavuz, and A. Ozel's remarks concerning adverse and possibly pathogen effects of clofibrate in man are very important and deserve accurate answers. The potential carcinogenic effect of clofibrate in rat and mouse is well known; its mechanism has not been resolved, but it occurs only after extended treatment involving high doses of the drug.1-4 In man, some authors have speculated on the possible occurrence of colonic tumors, due to the increase in fecal excretion of cholesterol, degradation of which by intestinal bacteria might produce carcinogenic substances.5,6
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