Abstract

Chronic lymphocytic leukemia (CLL) is an actual issue of oncology due to the increase of morbidity, frequent and therapy-resistant relapses, the development of infectious complications, commonly leading to the unfavorable prognosis. The identification of diagnostic features and management outcomes of infectious complications in CLL. We realized the case-control study of 82 CLL patients, who were treated at the Institute of Oncology in Moldova between 2000-2021. The diagnosis was proved according to the IWCLL criteria based on the complete blood count with the detection of lymphocytosis ≥ 5×109/l, bone marrow aspiration with lymphocytic infiltration ≥30% and immunophenotyping. The study was related to the outpatient and hospitalized care. The study included CLL patients of 45-86 years old (median age 66.2 years). There were 47 men (57.3%) and 35 women (42.7%). According to the Binet Classification, 54 (65.9%) patients were placed in stage A and 28 (34.1%) in stage B. The overall survival (OS) estimated the long-term results. The study of the age structure revealed the predominance of patients of 60-79 years old. Twenty-two (40.8%) stage A patients experienced the CLL transformation into stage B. Transformation into stage C was observed in 10 (35.7%) patients. The respiratory bacterial infections turned out to be frequently diagnosed (29 patients, or 80.6%): acute pneumonia in 10 (27.8%), acute bronchitis in 7 (19.4%), relapse of chronic bronchitis in 11 (30.6%), and tuberculosis in 1 (2.8%) patient. Viral herpetic complications were diagnosed in 2 (5.6%) cases. Infectious complications of the other systems were detected in 5 (13.8%) patients: nephro-urinary infections in 3 (8.2%) and acute otitis in 2 (5.6%). Death occurred over a period of 3-19 years in 16 (19.5%) patients, due to infectious complications in 6 (37.5%), as a result of CLL progression in 5 (31.3%), due to the secondary tumors in 4 (25.0%), and acute cerebrovascular accident in 1 (6.2%). The 3- and 5-year OS was 100% and 95.7% in patients with stage A and 84.8% and 55.4% in stage B. Infectious complications are frequent manifestations and cause of death in CLL, especially in stage B.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call