Abstract
The main goal of the present study was to investigate the microencapsulation, in vitro release capacity and efficiency of catechin-rich Acacia catechu extract by Clinosorbent-5 (CLS-5) microparticles by in-depth detailed analyses and mathematical modelling of the encapsulation and in vitro release kinetics behaviour of the polyphenol-mineral composite system. The bioflavanol encapsulation and release efficiency on/from the mineral matrix were assessed by sorption experiments and interpretative modelling of the experimental data. The surface and spectral characteristics of the natural bioactive substance and the inorganic microcarrier were determined by Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet/Visible (UV/Vis) spectrophotometric analyses. The maximum extent of catechin microencapsulation in acidic medium was 32%. The in vitro release kinetics study in simulated enzyme-free gastric medium (pH = 1.2) approved 88% maximum release efficiency achieved after 24 h. The in vitro release profile displayed that the developed bioflavanol/clinoptilolite microcarrier system provided sustained catechin in vitro release behaviour without an initial burst effect. Thus, the results from the present study are essential for the design and development of innovative catechin-CLS-5 microcarrier systems for application in human and veterinary medicine.
Highlights
The potential applications of clinoptilolite as a promising drug-carrier material for biomedicine and pharmaceutics were intensively studied and reviewed, especially up to the first decade of the XXI century
The main goal was to investigate the microencapsulation and in vitro release capacity and efficiency of catechin-rich Acacia catechu extract by Clinosorbent-5 (CLS-5) microparticles by in-depth detailed analyses and mathematical modelling of the encapsulation and in vitro release kinetics behaviour of the polyphenol-mineral composite system
The chemical content and physicochemical properties of CLS-5 are presented in Reference [29]
Summary
The potential applications of clinoptilolite as a promising drug-carrier material for biomedicine and pharmaceutics were intensively studied and reviewed, especially up to the first decade of the XXI century. Topashka-Ancheva et al established that the structure of chromosomes and red blood cells, as well as the mitotic index and erythropoiesis, was significantly improved by the supplementation of Pb-exposed laboratory mice the with clinoptilolite sorbent clinosorbent KLS-10-MA, based on natural Bulgarian clinoptilolite. These findings ascertained that the clinoptilolite sorbent KLS-10-MA exerted a significant favourable effect and could be applied as a reliable tool for detoxification of human and animal organisms chronically poisoned by heavy metals [9]
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