Clinicopathology characteristics of idiopathic membranous nephropathy in elderly patients

Abstract

Objective To investigate the clinicopathological characteristics of idiopathic membranous nephropathy (IMN) in elderly patients. Methods Clinicopatholigical data of 400 patients with IMN identified by renal biopsy from January 2006 to December 2016 were analyzed retrospectively. The patients were divided into three groups: the young (≤44 years old), the middle-aged (45-59 years old) and the elderly (≥60 years old) , and the clinicopathological characteristics were compared among three groups. Results The average age of the elderly group was( 64.9±4.3)years, the elderly group had worse renal function than the young group (F=784.60, P=0.000) and the middle-aged group [estimated glomerular filtration rate(eGFR)were (91.1±25.9) 、(119.8±37.0) and (102.5±33.2) ml·min-1·1.73 m-2,F=21.74, P=0.000]. The incidence of hypertension was higher in the elderly group than the other two groups [40.0%(32/80) vs. 19.6%(30/153) and 22.2%(37/167), χ2=12.76, P=0.003]. The incidence of MN with ischemic nephropathy and tubulointerstitial lesion in the elderly group was higher than in the young group[15.0%(12/80) vs. 5.8%(9/153), χ2=5.31, P=0.021]. Conclusion The elderly patients with IMN are likely to be complicated with hypertension, ischemic nephropathy and tubulointerstitial lesions indicating poorer prognosis, so more attention should be paid to the early diagnosis and treatment of these comorbidities. Key words: Nephrosis; Glomerulone-phritis, membranous; Pathological conditions, signs and symptoms; Age groups