Abstract
BackgroundOral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst. This is a retrospective study of oral OFM diagnosed over a period of 42 years at an oral pathology service.Material and MethodsClinical, histopathological and immunohistochemical data were analyzed. Alcian blue staining and S-100 immunohistochemistry were performed.ResultsEleven cases were retrieved (4:1 female-to-male ratio). The mean age was 44 years. The gingiva was the most affected site. The main clinical presentation was sessile or pedunculated lesions of fibrous or hyperplasic appearance, most of them asymptomatic. Positive Alcian blue staining and absence of S-100 protein were observed in all specimens, which supported the histological diagnosis of OFM. Surgical excision was the treatment of choice.ConclusionsAlthough rare, this study supports the inclusion of OFM in the differential diagnosis of intraoral myxoid lesions. Key words:Oral focal mucinosis, myxomatous lesion, connective tissue diseases, diagnosis.
Highlights
Oral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst
Among the 14,204 oral lesion biopsies obtained over a period of 42 years and retrieved from the archives of the Oral Pathology service, 11 cases (0.07%) were diagnosed as OFM
Histochemical staining with Alcian blue was positive (Fig. 2A) and immunohistochemical staining with antiS-100 antibody was negative in all cases (Fig. 2B)
Summary
The aim of this study was to retrospectively analyze the clinical and histological data of 11 OFM cases diagnosed at a referral service for Oral Pathology. Oral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst. Conclusions: rare, this study supports the inclusion of OFM in the differential diagnosis of intraoral myxoid lesions
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