Abstract

A clinico-pathological study of 90 cases of stage-I malignant melanoma was made after a follow-up period of 2 to 16 years for the survivors, with an average follow-up period of 4.7 years, in an attempt to determine the prognostic significance of invasion level, chosen treatment plan, microscopic evidence of node involvement and predominant cytology of the tumor. Several important findings were made: there was a significant difference in the survival of patients between invasion levels III and IV, but not between IV and V ; immediate radical treatment was significantly more successful than either of the conservative methods investigated; the presence of microscopical deposits of tumor in nodes significantly worsened the prognosis; and patients with small cell tumors had significantly less chance of survival than those with large cell tumors.

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