Abstract
BackgroundPlasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasma cell dyscrasias. They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary Extramedullary Plasmacytoma (SEP) and multiple solitary plasmacytomas (MSP). In this study, we discuss the clinical, histopathological and immunohistochemical characteristics of solitary plasmacytomas.MethodsA 13 year retrospective analysis of solitary plasmacytomas was performed from a single tertiary care center. Bone marrow evaluation was done concurrently at the time of diagnosis to rule out the presence of multiple myeloma.ResultsA total of 29 cases fulfilled the diagnostic criteria for SP during the study period. SPB accounted for 55.2%, SEP for 44.4% and MSP for 3.4% of the cases. The most common sites involved were the paranasal sinuses and vertebrae. Other infrequent sites included lymph node, tonsil and lungs. The mean age of presentation of SPB was a decade later than SEP. A male preponderance was observed in both subtypes.ConclusionSolitary plasmacytoma is a rare entity, the diagnosis of which requires a systematic approach. There is limited data available in the literature on the clinico-pathological characteristics of SP from India.
Highlights
Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms
Solitary plasmacytomas (SP) are rare neoplasms, that often occur with the absence of systemic manifestations and bone marrow involvement, but do have a propensity to eventually progress to MM [6]
In a total of 130,496 histopathological specimens reported during the study period, plasmacytomas accounted for 57 cases
Summary
Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasma cell dyscrasias. They encompass three subtypes - Solitary Plasmacytoma of Bone (SPB) and Solitary Extramedullary Plasmacytoma (SEP) and multiple solitary plasmacytomas (MSP). At one end of the spectrum, lies Monoclonal Gammapathy of Undetermined Significance (MGUS) which is a silent disorder, while at the other end lies the more aggressive entity, multiple myeloma (MM) [1]. Solitary plasmacytomas (SP) are rare neoplasms, that often occur with the absence of systemic manifestations and bone marrow involvement, but do have a propensity to eventually progress to MM [6]. SP may be either solitary plasmacytoma of the bone (SPB), solitary extramedullary (extra-ossesous) plasmacytoma (SEP) or multiple
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