Abstract
BackgroundKAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC).MethodsTumor tissue specimens from 312 resected patients with stage I–IIIA NSCLC were obtained. Immunohistochemistry was used to assess the expression of the molecular markers KAI1, E-cadherin (E-cad), vimentin, CD34, and D2-40.ResultsThere were 153 N0 and 159 N+ patients. Tumor cell expression of KAI1and the marker of EMT, lymphatic vessel density (LVD), and microvessel density (MVD) were related to LNM. In multivariate analyses, the ages of patients, high tumor cell KAI1 expression, EMT, and the scores of MVD were independent factor of prognosis.ConclusionsTumor cell KAI1 expression, EMT, LVD, and MVD correlate with LNM. Thus, the detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of NSCLC prognosis.
Highlights
KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies
Tumor cell KAI1 expression, EMT, lymphatic vessel density (LVD), and microvessel density (MVD) correlate with lymph node metastasis (LNM)
The detection of KAI1, expression of markers of EMT, and the scores of MVD may be used as a potential indicator of non-small cell lung cancer (NSCLC) prognosis
Summary
KAI1 and epithelial-mesenchymal transition (EMT) is related to both angiogenesis and lymphangiogenesis and is an important target in new cancer treatment strategies. We aimed to investigate the KAI1 and marker of EMT expression and correlation with lymph node metastasis (LNM) and explore their prognostic impact in non-small cell lung cancer (NSCLC). About 65 % non-small cell lung cancer (NSCLC) patients who are suitable for surgical procedures will relapse within 2 years and subsequently die of metastatic spread [2, 3]. KAI1 gene was originally identified as a suppressor of metastasis of tumor in prostate cancer and located on human chromosome 11p11.2 [4]. It is a member of the tetraspanins superfamily of glycoproteins.
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