Clinicopathological Significance of Heat Shock Protein (HSP) 27 Expression in Gastric Cancer: A Updated Meta-Analysis.

Tong Liu,Mei Dong,Xiangxue Kong,Duo Liu

doi:10.1155/2020/7018562

Abstract

Aim HSP27 is a protein chaperone protecting cell from heat shock, and upregulated HSP27 expression has been found in many different cancers. We conduct this update meta-analysis to evaluate the relationship between HSP27 expression and clinicopathological features. Methods We searched PubMed, Chinese CNKI, and WanFang databases to identify studies that assessed the association between clinicopathological feature and HSP27 expression in gastric cancer patients. Results We found overexpression of HSP27 was associated with incidence of gastric cancer (OR = 6.31, 95% CI = 1.10–36.15, P < 0.0001). However, there was no significant difference between HSP27 expression and gastric cancer differentiation, gender difference, lymph node metastasis, and distant metastasis. Conclusion Our meta-analysis study indicates that overexpression of HSP27 is associated with incidence of gastric cancer statistically.

Highlights

Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally [1]
We searched PubMed, Chinese CNKI, and WanFang databases to identify studies that assessed the association between clinicopathological feature and HSP27 expression in gastric cancer patients. e search ended in September 1, 2019
E included criteria for this study were as follows: (1) patients were diagnosed as gastric cancer; (2) HSP27 expression was tested in tissue of gastric patients by immunohistochemistry (IHC); (3) study design was case-control study or cross-sectional study; (4) studies included at least one primary outcome of interest; and (5) study was published in English or Chinese with full text available

Summary

Introduction

Gastric cancer is the second leading cause of cancer-related mortality and the fourth most common cancer globally [1]. In 2014, 410,400 new stomach cancer cases and 293,800 cancer-associated deaths were estimated to have occurred in China. E crude incidence rate of stomach cancer was 30.00/100,000, and the crude mortality rate of stomach cancer was 21.48/100,000 [2]. SHSPs bind to a wide range of cellular proteins and are implicated in several cellular functions, apart from providing protection against various environmental and physical stressors, such as high temperature and chemical toxins [3]. High expression levels of HSP have been reported in many cancers, including breast, head and neck, gallbladder, colorectal, skin, liver, colon, renal, prostate, and ovarian cancer [4, 5]. HSP27 can suppress other apoptotic death receptor pathways, including TNFα, Fas, and TRAIL [12]

Methods

Results

Conclusion