Abstract
Many types of KIT mutations have been observed in gastrointestinal stromal tumors (GISTs), but their prognostic and predictive significance are still unclear. A meta-analysis and literature review were conducted to estimate the contribution of KIT mutations in prognostic parameters and clinic-pathological significance of GISTs. A total of 18 relevant articles from PubMed, EMBASE and Web of Science databases were included in this study. The frequency of KIT mutation was significantly increased in the GIST patients with higher mitosis (≥5/50 high-power fields (HPFs) and larger size (≥5 cm) of tumors than in those with lower MI (≤5/50HPFs) and smaller size (≤5 cm) of GISTs respectively. The rate of KIT mutation was not significantly changed between GISTs in stomachs and in small intestines. KIT mutational status has prognostic significance for patients’ outcome. GIST patients with KIT exon 9 mutations have higher risk of progression than those with exon 11 mutations. 5 year relapse-free survival (RFS) rate was significantly higher in patients with KIT exon 11 deletion than in those with other type of KIT exon 11 mutations. The deletion involving KIT exon 11, particularly codons 557–558, is a valuable predictor of prognosis for patients with GISTs.
Highlights
Cells of Cajal which was associated with Auerbach’s nerve plexus and intestinal pacemaker activity, indicating that the interstitial cells of Cajal express the KIT receptor[8]
The following items were collected from each study: first author’s name, year of publication, number of patients, countries, the number of mitosis per 50 HPFs in Gastrointestinal stromal tumors (GISTs), tumor size, c-KIT mutation, treatment and the time of follow-up (Table 1)
Our analysis showed that KIT mutation was not associated with the risk of mortality of patients with GISTs
Summary
Cells of Cajal which was associated with Auerbach’s nerve plexus and intestinal pacemaker activity, indicating that the interstitial cells of Cajal express the KIT receptor[8]. Many types of KIT mutations have been observed in GISTs, but controversy still exists concerning their prognostic and predictive value[10]. Deletions in the KIT exon 11 most frequently involve the 5′ portion between codons 550 and 56011. A few studies have shown that tumors containing deletion in this area are clinically more aggressive than tumors with other type of mutations.
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