Abstract
Background:The prognostic factors for survival in squamous cell carcinoma (SCCA) of vulva cancer such as groin node involvement, postmenopausal status, tumor size, margin status, tumor grade, lymph vascular space invasion (LVSI) were reported in the past. However, with limited data from Southeast - Asian population, the present study was conducted to evaluate the clinicopathological prognostic factors for survival outcomes of this disease after treatment with surgery.Methods:All SCCA vulva cancer patients who underwent surgery between January 2006 and December 2017 were reviewed. The clinicopathological factors were analyzed to identify the prognostic factors for the progression-free survival (PFS) and overall survival (OS) using the Kaplan- Meier method and Cox-Proportional Hazard model. Results:One hundred twenty-five patients were recruited. The independent poor prognostic factors for PFS were groin node-positive and pathologic tumor diameter of more than 25 mm. Whereas postmenopausal status and groin node positive were independent poor prognostic factors for OS. Conclusion:Groin node-positive was the only one independent poor prognostic factor for both PFS and OS. In addition, the tumor diameter longer than 25 mm. was independent poor prognostic factors for PFS while postmenopausal status was independent poor prognostic factors for OS. Special adjuvant treatment for patients with these factors should be further investigated.
Highlights
Vulva cancer is a rare gynecologic cancer
We recently reported a series of all stage of 145 squamous cell carcinoma (SCCA) vulva cancer patients who treated at our institute and found the common recurrent sites were groin and vulva regions with unfavorable survival outcomes (Meelapkij et al, 2018)
Study Population After the protocol was approved by the local ethics committee, the medical records of the vulva cancer patients with SCCA treated at Chiang Mai University Hospital from January 2006 through December 2017 treated according to general practice guideline of our institute were reviewed
Summary
The first type is human papillomavirus (HPV) related. This type typically is found with a high-grade squamous cell intraepithelial lesion (HSIL) and is associated with the immunosuppressive state, smoking, and usually occurs in the younger age population. The prognostic factors for survival in squamous cell carcinoma (SCCA) of vulva cancer such as groin node involvement, postmenopausal status, tumor size, margin status, tumor grade, lymph vascular space invasion (LVSI) were reported in the past. The independent poor prognostic factors for PFS were groin node-positive and pathologic tumor diameter of more than 25 mm. Whereas postmenopausal status and groin node positive were independent poor prognostic factors for OS. Conclusion: Groin node-positive was the only one independent poor prognostic factor for both PFS and OS. Special adjuvant treatment for patients with these factors should be further investigated
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