Clinicopathological features, surgical procedures and prognosis of gastric cancer patients with single organ invasion

Abstract

Objective To invastigate the clinicopathological features,surgical procedures,prognosis of gastric cancer cases with single organ invasion.Method According to morbility,in an order from high to low,288 cases of gastric cancer with single organ invasion,were divided into group of pancreas (n =83),transverse colon or mesocolon(n =71),esophagus(n =53),and duodenum invasion(n =21).Clinicopathological features,surgical procedures and prognosis were compared among groups.Results In group of esophagus invasion,the ratio of distal metastasis,peritoneal metastasis,pTNM stage was 9％,8％,34％ respectively,all was the lowest among all groups(all P ＜0.05).The ratio of cases receiving radical resection in esophagus invasion group was 93％ (P ＜ 0.05),whereas,the ratio of patients receiving extended lymphadenectomy was 25％ in pancreas invasion group (all P ＜ 0.05).Univariate survival analysis showed organ invasion was the prognostic factor.The median survival time was 15.4,17.5,30.9,14.1 months in group of pancreas,transverse colon or mesocolon,esophagus,duodenum invasion respectively,and in cases who received radical resection,it was 23.8,19.7,35.8,17.4 months respectively,all with significant difference (all P ＜ 0.05).Among groups,the prognosis was not significantly different in those receiving palliative resection (P ＞ 0.05).Conclusions Compared with other adjoining single organ invasion,gastric cancer patients with esophagus invasion are often with earlier TNM stage,higher ratio of radical resection and better prognosis.Radical resection improves the prognosis of gastric cancer patients with single organ invasion. Key words: Stomach neoplasms ; Neoplasm invasiveness ; Prognosis ; Pathology, clinical