Abstract
To investigate the clinicopathological characteristics and survival of small cell carcinoma of the cervix using Surveillance, Epidemiology, and End Results database. Patients with a diagnosis of small cell carcinoma of the cervix were included between 1988 and 2012. Kaplan-Meier method and Cox regression models were used. A total of 487 patients were included. Of the patients with known International Federation of Gynecology and Obstetrics stage and tumor grade, the stage IV disease was diagnosed in 37.9% patients, and 98.5% patients had poorly or undifferentiated histology. The 5-year cause specific survival and overall survival were 33.0% and 29.4%, respectively. In multivariate analysis, increasing age, advanced stage, and treatment by primary radiotherapy were associated with worse survival outcomes. Small cell carcinoma of the cervix is a rare disease with aggressive characteristics and prone to metastasize and is dismal in prognosis. Reduced survival was associated with increasing age, advanced stage, and treatment by primary radiotherapy.
Highlights
According to the National Cancer Institute, there were approximately 12,900 new cases diagnosed and 4,100 deaths due to cervix cancer in 2015 [1]
Reduced survival was associated with increasing age, advanced stage, and treatment by primary radiotherapy
The incidence of Small cell carcinoma of the cervix (SCCC) differed significantly according to age group
Summary
According to the National Cancer Institute, there were approximately 12,900 new cases diagnosed and 4,100 deaths due to cervix cancer in 2015 [1]. About 90% of cervical cancer patients are squamous cell carcinoma. Small cell carcinoma of the cervix (SCCC) is a rare disease accounting for approximately 2–5% of uterine cervix malignancies [2,3,4]. Like small cell carcinoma in other body sites, SCCC is highly invasive and prone to distant metastatic spread [3, 4, 6,7,8], causing poorer prognosis than other types of cervical cancer. The clinicopathological features and biological behavior of SCCC in above studies were including limited number of patients. The aims of this study were to investigate the clinicopathological characteristics and survival in patients with SCCC using Surveillance, Epidemiology, and End Results (SEER) database
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