Abstract
Objective To investigate the clinicopathological characteristics of non-small cell lung cancer (NSCLC) patients with human epidermal growth factor receptor-2 (HER2) gene mutation. Methods A second-generation sequencing was performed on the pathological specimens of 291 NSCLC patients in the First Affiliated Hospital of Zhengzhou University from Januart 2016 to January 2018, and the clinical and pathological characteristics of 23 patients with HER2 gene mutation were retrospectively analyzed. Results The positive expression rate of HER2 gene in NSCLC patients was 8%(23/291). The mutation rate of patients with family history of cancer was higher than that of patients without family history of cancer (18.87% vs. 5.46%, P=0.001). The mutation rate of HER2 in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (10.65% vs. 0.00%, P=0.003). The mutation rate in patients with clinical stage Ⅲ-Ⅳ was higher than that in patients with clinical stage Ⅰ-Ⅱ (9.91% vs. 0.00%, P=0.012). The mutation rate of patients with bone metastasis was significantly higher than that of patients without bone metastasis (14.29% vs. 3.49%, P=0.001), and the mutation rate of patients with brain metastasis was higher than that of patients without brain metastasis (17.33% vs. 4.63%, P=0.000). There was no significant difference in HER2 positive expression rate among patients with different age, genders, smoking history or pathological classifications (P>0.05). Conclusions In NSCLC patients, HER2 mutation is mostly found in the population with family history, lymph node metastasis, brain metastasis and bone metastasis, and the clinical stage in the middle and late stage, which may be predictors of poor prognosis of the disease. Therefore, it is recommended to carry out HER2 gene test in such patients. Key words: Non-small cell lung cancer; Human epidermal growth factor receptor-2 gene mutations; Clinical features; Prognosis
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