Clinicopathological evaluation of non-infectious, non-neoplastic skin biopsies in a tertiary care centre of Eastern India

Abstract

Background: Non-neoplastic skin lesions have different histomorphological features and need clinical correlations in order to arrive at a definitive diagnosis. Aim: The objective was to study the incidence rates of various non-neoplastic skin lesions and to correlate with clinical diagnosis as well as patient demographic profiles. Materials and Methods: It is a retrospective study conducted in the department of pathology over a period of June 2014 to June 2018. A total of 254 skin biopsies were reviewed and correlated with clinical findings. Haematoxylin- and eosin-stained slides were evaluated along with special stains in most of the cases. Results: Out of 254 non-neoplastic skin lesions, erythematous and papular lesions were most common (52.7%), followed by vesiculobullous lesions (17.3%). Pigmentary lesions comprised 11.4%, photosensitivity reactions 2.7% and vascular lesions 2.3% of the total cases. Out of 254 cases, 169 were males and 85 were females, with a male-to-female ratio being 1.9, and their age ranged from 4 months to 75 years. The most common age group was 21–30 years. Lower limb skin was most commonly involved (40.1%) followed by upper limb, trunk and least common site was head and neck (14.9%). Conclusion: Erythematous and papular lesions were the commonest and involved the young adults most frequently. Considering common sites, clinical presentations are of significant importance in diagnosing non-neoplastic skin dermatoses.