Abstract
The nucleotide excision repair pathway is a sophisticated DNA repair mechanism that reduces DNA damage caused by exogenous factors. Excision repair cross complementation group 1 (ERCC1) is a prominent member of this pathway that maintains the genomic stability. The aim of this study is to determine the association between the immunohistochemical expression of ERCC1and the clinical and pathological features of oral cavity squamous cell carcinomas. The sections of formalin fixed paraffin embedded tissue blocks of oral squamous cell carcinomas (n=60) were immunohistochemically stained with anti-ERCC1antibody. Theassociation between the nuclear expression of ERCC1and the clinicopathological parameters of the tumors and the patient outcomes was evaluated using the chi-square test. ERCC1expression was evident in all studied cases of the oral squamous cell carcinomas. A high ERCC1expression was associated with smaller tumors, tumors without lymph node involvement and well-differentiated tumors (p<0.001). Better outcomes were associated with higher expression of ERCC1 (p=0.028). ERCC1seems to be an efficient biomarker for prognostication of oral squamous cell carcinomas. High expression of ERCC1indicates more favorable course of the disease.
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