Clinicopathological characteristics in hereditary nonpolyposis colorectal carcinoma-associated endometrial carcinoma

Abstract

To study clinicopathological characteristics of hereditary nonpolyposis colorectal carcinoma (HNPCC)-associated endometrial carcinoma (EC). Totally 421 EC patients admitted to General Hospital of Tianjin Medical University from 1981 to 2006 were divided into three groups: group A: sporadic EC; group B: familial aggregation of EC; group C: HNPCC-associated EC. HNPCC-associated EC accounted for 6.4% (27/421). Mean age at time of diagnosis was 49.7 years in group C, earlier than 56.3 years in group A (P = 0.004) and 55.2 years in group B (P = 0.035). There were 33.3% (9/27) patients with multiple primary carcinomas in group C. It was higher than 14.3% (9/63) in group B and 5.1% (17/331) in group A respectively (P = 0.038, P < 0.01). There was no difference among the three groups in histological type or menopausal status (P > 0.05). The numbers of patients with low grade EC in group C (70.4%, 19/27) and group B (61.35, 38/62) were more than that in Group A (P = 0.013, P = 0.023). Prognosis for group C was better than that in group A (P = 0.021), and 5- and 10-year survival rate in groups A, B and C was 80%, 70%; 88%, 85%; and 96%, 96% respectively. Mean age at time of diagnosis is earlier in HNPCC-associated EC than that in sporadic EC; patients with HNPCC-associated EC are more frequently complicated with multiple primary carcinomas and of low grade; prognosis is better.