Abstract
To investigate clinicopathological features in patients with recurrent colorectal cancer within 1 year and more than 1 year after curative resection. We retrospectively evaluated 103 patients with disease recurrence before versus after 1 year of resection. Thirty-two patients (31%) were diagnosed with recurrence less than 1 year after curative resection for colorectal cancer (early recurrence) and 71 (69%) after more than 1 year (non-early recurrence). The early recurrence group displayed a significantly lower overall survival rate for both colon cancer (p=0, 01) and rectal cancer (p<0.001). Inadequate lymph node dissection was a significant predictor for early relapse. There were no statistically significant differences in clinicopathological variables such as age, sex, primary tumor localization, stage, depth of invasion, lymphovascular invasion and perineural invasion between the early and non-early recurrence groups. However, a K-ras mutation subgroup was significantly associated with early recurrence (p<0.001). Poor survival is associated with early recurrence for patients undergoing resection for non-metastatic colorectal cancer, as well as K-ras mutation.
Highlights
The incidence of colorectal cancers (CRC) has increased and the third most common neoplasm in Turkey and in the world in recent years (Jemal et al, 2010; Karaca et al, 2011)
Recurrence after surgical resection for colorectal cancer may be associated with clinicopathological parameters such as lymphovascular invasion, an unfavorable genotype, deeper tumor invasion, advanced cancer stage, lymph node metastasis and chemotherapy resistance
Tsai et al observed that the overall survival rate in the early recurrence group was significantly lower than that of the non-early recurrence group (Tsai et al, 2009)
Summary
The incidence of colorectal cancers (CRC) has increased and the third most common neoplasm in Turkey and in the world in recent years (Jemal et al, 2010; Karaca et al, 2011). It has been determined that the overall recurrence rate of colorectal cancer after curative surgery is between 26 and 43 % according to the duration of follow-up and the initial pathological stage of disease (Galandiuk et al, 1992; Moertel et al, 1993; Kjeldsen et al, 1997; Graham et al, 1998). The majority of these recurrences occur during the first 5 years after surgery (Galandiuk et al, 1992; Kjeldsen et al, 1997; Graham et al, 1998). We investigated the clinicopathological features in patients with recurrent colorectal cancer within 1 years or more than 1 years after curative resection and determined the predictors of survival after recurrence
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
