Abstract
Although certain characteristics of renal cell carcinoma (RCC) seen in Sri lanka are different to the developed world and incidence is rising, no data on oncological outcome and patient survival are avaialble. A hospital-based cohort study was done in a tertiary referral centre over a period of eight years (2012-2019). A total of 285 newly diagnosed RCC had a mean follow-up period of 28.3 months. Radical nephrectomy was performed in 189 patients while 91 patients had partial nephrectomy. Clear cell RCC which was seen in 231 (81.1%) patients while papillary RCC was seen in 43 (15.1%). There were 54 deaths during the follow-up. The 30-day postoperative mortality was 2.1%. Thirty (10.5%) patients developed metastases while three patients developed local recurrences. The overall five -year survival rate was 72.8% (95%CI=65.9-80.5). Five-year survival of papillary RCC (60.5%) was lower than clear cell RCC (74.1%). Tumour stage, presence of metastases and histological grade of the tumour influenced the survival. Gender (p= 0.3), histological type (p= 0.5) or type of surgery (p=0.2) had no statistically significant effect on survival.
Highlights
Renal cancer accounts for 5% of all cancers in men and 3% of all cancers in women [1]
The crude incidence of renal cancer in Sri Lanka is 1.3 per 100 000 population according to latest available statistics of National Cancer Registry for the year 2014 in which 255 new cases of Renal cell carcinoma (RCC) had been reported [2]
Adult (≥18 years) patients who had treatment for histologically confirmed renal cell carcinoma in the urology unit, Colombo South Teaching Hospital (CSTH) from 1 January 2012 to 31 December 2019 were eligible to be included in the study
Summary
Renal cancer accounts for 5% of all cancers in men and 3% of all cancers in women [1]. Renal cancer is the 13th most common malignancy, with approximately 338 000 new cases diagnosed in each year. Renal cell carcinoma (RCC) accounts for 90% of all renal malignancies. An increase in RCC has been observed globally, in recent years incidence of RCC has declined in some European countries namely Sweden, Poland, Finland and Netherlands. The crude incidence of renal cancer in Sri Lanka is 1.3 per 100 000 population according to latest available statistics of National Cancer Registry for the year 2014 in which 255 new cases of RCC had been reported [2]. In 2010, only 169 cases of renal cancer were reported to the National Cancer Registry [3]
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