Clinicopathological characteristics and expression of Topo IIα, Ki67 in triple negative breast cancer

Abstract

Objective To investigate the clinicopathological characteristics and the expression of Topo Ⅱ α,Ki67 in triple negative breast cancer (TNBC).Methods The clinicopathological characteristics in TNBC group were analyzed,including year,tumor size,lymph node metastasis and histological type; the expression of Topo Ⅱ α and Ki67 was determined by immunohistochemical techniques (EnVision).And we compared the differences between TNBC group (78 cases) and the non-triple negative breast cancer (nonTNBC) group (114 cases).Results The positive rate of axillary lymph node metastasis in TNBC group was higher than that in non-TNBC group,which difference was significant (P ＜ 0.05) ; With the increase of the tumor size,the positive rate of axillary lymph node metastasis in TNBC group was significantly higher,The positive rate of axillary lymph node metastasis was correlated positively with the tumor size (P ＜ 0.05) ;the expression of Ki67 in non-TNBC group was significantly lower than that in TNBC group (x 2=4.003,P=0.045).Conclusion Compared with non-TNBC group patients,TNBC group patients have a higher risk of local invasion,lymph node metastasis,cell proliferation and poorer survival. Key words: Breast neoplasm; Triple negative; Topo Ⅱα ; Ki67