Abstract
BackgroundInfective dermatitis associated with human T-cell lymphotropic virus type-1 (HTLV-1), (IDH), is a chronic eczema occurring in HTLV-1 infected children. Rare cases of adulthood IDH have been reported and no study until now aimed to compare juvenile and adulthood IDH.Methodology/Principal findingsTwelve cases of adulthood IDH followed for a mean time of 7.5 years were analyzed according to clinicopathological and molecular aspects, comparing them to juvenile IDH cases. Diagnosis was based on the modified major criteria used for juvenile IDH. Proviral load (PVL) assessment was performed by real-time PCR technique. Adulthood IDH presented similar clinicopathological and molecular aspects compared to juvenile IDH. The morphology of lesions and areas of involvement were similar, except for the involvement of the ankles and inframammary folds in the adulthood form. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) occurred in six adulthood IDH patients, with almost equal frequency. However, at least in two patients, HAM/TSP appeared prior to IDH, differently from what was observed in juvenile IDH.Conclusions/SignificanceAdulthood IDH is similar to juvenile IDH according to clinicopathological aspects and PVL levels. Therefore, the same modified major diagnostic criteria for juvenile IDH can be applied to both forms.
Highlights
Infective dermatitis associated with the human T-cell lymphotropic virus type-1 (HTLV-1), (IDH) is a chronic and severe form of childhood eczema characterized by an exudative and infected dermatitis, always involving the scalp and retroauricular regions
infective dermatitis associated with HTLV-1 (IDH) is frequently associated with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a myelopathy of insidious onset characterized by bladder disturbances, mild sensory involvement and slowly progressive spastic paraparesis [2]
In only one patient it was possible to text for HTLV-1 serology her mother and her mother was negative
Summary
Infective dermatitis associated with the human T-cell lymphotropic virus type-1 (HTLV-1), (IDH) is a chronic and severe form of childhood eczema characterized by an exudative and infected dermatitis, always involving the scalp and retroauricular regions. IDH is frequently associated with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a myelopathy of insidious onset characterized by bladder disturbances, mild sensory involvement and slowly progressive spastic paraparesis [2]. Progression of IDH to juvenile HAM/TSP has been observed in 54% of the juvenile IDH cases [3]. In Bahia, Brazil, familial clustering of IDH and HAM/TSP has been found in 15 families, 93% in two generations [4]. Infective dermatitis associated with human T-cell lymphotropic virus type-1 (HTLV-1), (IDH), is a chronic eczema occurring in HTLV-1 infected children.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
