Abstract
The long intergenic non-coding RNA SNHG7 has been reported to be abnormally expressed in many types of cancer, the results remain controversial. In this study, a meta-analysis was performed to evaluate the clinicopathologic and prognostic value of SNHG7 in cancers. Electronic databases of PubMed, Web of Science, Cochrane Library and Embase were used to search relevant studies. A combined hazard ratio (HR) and its corresponding 95% confidence interval (CI) were used to assess the association between SNHG7 expression and prognosis in cancer patients. Pooled odds ratio (OR) and 95% CI were calculated to elaborate the association between SNHG7 expression and clinicopathological features in cancers. Besides, the data from The Cancer Genome Atlas (TCGA) dataset was used to validate the results. In total, eighteen studies compromising 1303 participants were enrolled in this analysis. The pooled results showed increased SNHG7 expression could predict unfavorable overall survival (OS) (HR = 1.75, 95%CI = 1.52–2.02, P = 0.000). Analysis stratified by follow-up time, cancer types, analysis types, sample sizes and cut off further verified the prognostic value of SNHG7. Additionally, elevated SNHG7 expression was correlated with TNM stage (OR: 3.31, 95%CI = 2.29–4.80, P = 0.000), lymph node metastasis (OR = 3.32, 95%CI = 1.61–6.83, P = 0.004), and tumor differentiation (OR = 1.92, 95%CI = 1.22–3.03, P =0.005) in patients with cancers. Excavation of TCGA dataset valuated that SNHG7 was upregulated in some cancers and predicted worse OS, which partially confirmed our results in this meta-analysis.
Highlights
Cancer has been recognized as one of the most serious public health problems on a global scale
The number of studies involved in distance metastasis (DM), lymph node metastasis (LNM), TNM stage, and tumor differentiation was 6, 10, 6, and 6 respectively
In hepatocellular carcinoma, Long non-coding RNAs (lncRNAs) NKILA has been reported for suppressing NF-κB/Slug pathway mediated with epithelial-mesenchymal transition to inhibit tumor metastasis [41]
Summary
Cancer has been recognized as one of the most serious public health problems on a global scale. It remains a high unmet need to discover new and effective biomarkers at an early stage to reduce cancer-related mortality. Many lncRNAs defined as oncogenes and tumor suppressor www.aging-us.com genes in various types of cancer, effect on the cancer cell proliferation and apoptosis and involve in cancer invasion and metastasis [7,8,9]. It has been reported that overexpressed LncSTCAT16 is a potent molecular target for inhibition of the cell proliferation and invasion in gastric cancer [11]. The up-regulation of LncPANDAR which promotes cell proliferation has been proved to related to poor prognosis of cervical cancer [12]. Many researchers believed that some of lncRNAs could become potential therapeutic targets for monitoring cancer, predicting prognosis and evaluation of treatment effect [13, 14]
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