Abstract
Objectives Many patients with papillary thyroid cancer (PTC) have a high recurrence risk and poor prognosis, and the main obstacle to the clinical diagnosis and treatment of PTC is lack of effective predictive molecular markers. The purpose of this study was to investigate the clinicopathological and prognostic implications of WW domain binding protein 5 (WBP5) expression in PTC. Materials and Methods Immunohistochemistry of WBP5 was performed using tissue microarrays of 131 patients with PTC who underwent surgery during January 2006 and January 2010 in the Zhejiang Cancer Hospital. Statistical analyses were conducted to evaluate the association between WBP5 expression and the clinicopathological features and to analyze the disease-free survival (DFS) and prognostic factors. Results and Conclusion The positive expression rate of WBP5 in PTC and the adjacent normal tissues was 42.75% (56/131) and 45.45% (10/22), respectively. WBP5 expression was significantly correlated with bilaterality, capsule invasion, and N-stage, and it was a favorable factor of DFS. Moreover, patients with a high WBP5 expression exhibited reduced risk of disease recurrence compared with that in patients with low WBP5 expression in the univariate analysis, whereas the multivariate analysis suggested that WBP5 was not an independent prognostic factor. Our results indicate that WBP5 might be a favorable prognosis indicator of PTC.
Highlights
A nal diagnosis was made based on postoperative histopathological examination, and some were recon rmed by immunohistochemistry (IHC). is study had excluded patients with other types of malignancies or undergone preoperative anticancer therapy. e clinicopathological characteristics, treatment methods, and clinical outcomes were summarized according to the medical records (Table 1). e tumor-node-metastasis (TNM) stage of the patients with papillary thyroid cancer (PTC) was determined according to the eighth American Joint Committee on Cancer recommendations [18]. e surgeon decided whether or not to perform total thyroidectomy according to preoperative ultrasonography and ultrasound-guided ne needle aspiration and intraoperative exploration
WW domain binding protein 5 (WBP5) Expression Was Signi cantly Decreased in PTC Tissue Compared with at in the Adjacent Normal Tissues. e results of Quantitative Real-Time Polymerase Chain Reaction (qPCR) showed that the expression of WBP5 in the adjacent normal tissues was signi cantly higher than that in PTC (Figure 1(a))
The the Cancer Genome Atlas (TCGA)-thyroid carcinoma data suggested that the expression of WBP5 was decreased in PTC (Figure 1(b))
Summary
Many patients with papillary thyroid cancer (PTC) have a high recurrence risk and poor prognosis, and the main obstacle to the clinical diagnosis and treatment of PTC is lack of e ective predictive molecular markers. e purpose of this study was to investigate the clinicopathological and prognostic implications of WW domain binding protein 5 (WBP5) expression in PTC. E purpose of this study was to investigate the clinicopathological and prognostic implications of WW domain binding protein 5 (WBP5) expression in PTC. Statistical analyses were conducted to evaluate the association between WBP5 expression and the clinicopathological features and to analyze the disease-free survival (DFS) and prognostic factors. WBP5 expression was signi cantly correlated with bilaterality, capsule invasion, and N-stage, and it was a favorable factor of DFS. Patients with a high WBP5 expression exhibited reduced risk of disease recurrence compared with that in patients with low WBP5 expression in the univariate analysis, whereas the multivariate analysis suggested that WBP5 was not an independent prognostic factor. Our results indicate that WBP5 might be a favorable prognosis indicator of PTC
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