Abstract
Several studies were conducted to explore the prognostic significance of Twist in non-small cell lung cancer (NSCLC), however, contradictory results in different studies were reported. To this end, we presented a systematic review aiming to summarize the prognostic significance of Twist in patients with NSCLC. 5 studies involving a total of 572 patients were identified. The result indicated that high Twist expression was significantly associated with a worse overall survival (OS) (hazard ratio (HR) = 2.19, 95% confidence interval (95% CI) = 1.64–2.94, p < 0.001; I2 = 0.0%, fixed effect), recurrence-free survival (RFS) (HR = 2.476, 95% CI = 1.728–3.547, p < 0.001; I2 = 0.0%, fixed effect) and lymph node or other metastasis (odds rate (OR) = 0.419, 95% CI = 0.259–0.679, P < 0.001, fixed effect). Subgroup analysis revealed that the expression of Twist in Chinese patients might be more closely associated with the prognosis of NSCLC than in American patients. Overall, these results indicated that Twist over-expression in patients with NSCLC might be related to poor prognosis and serves as an unfavorable predictor of poor clinicopathological prognosis factor.
Highlights
Primary lung cancer is the leading cause of cancer mortality worldwide among both men and women [1, 2], and non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer [3]
We presented a systematic review aiming to summarize the prognostic significance of Twist in patients with NSCLC. 5 studies involving a total of 572 patients were identified
The result indicated that high Twist expression was significantly associated with a worse overall survival (OS) (hazard ratio (HR) = 2.19, 95% confidence interval = 1.64–2.94, p < 0.001; I2 = 0.0%, fixed effect), recurrence-free survival (RFS) (HR = 2.476, 95% CI = 1.728–3.547, p < 0.001; I2 = 0.0%, fixed effect) and lymph node or other metastasis (odds rate (OR) = 0.419, 95% CI = 0.259–0.679, P < 0.001, fixed effect)
Summary
Primary lung cancer is the leading cause of cancer mortality worldwide among both men and women [1, 2], and non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer [3]. Epithelial to mesenchymal transition (EMT) is an epithelial cell into a mesenchymal cell with the ability to invade and migrate adjacent tissues It is a recent discovered cellular process in a wide variety of cancer cells, and it enhances the potential of tumor invasion, metastasis and chemoresistance [5, 6]. Twist-1(Twist) overexpression has been reported in a variety of epithelial cancer cells with clinical correlations with poor prognosis, an event associated with its capacity to promote EMT [16,17,18,19] and these malignancies include breast cancer [20], colorectal cancer [21], pancreatic ductal adenocarcinoma [22] and oral cancer [23]. We carried out a systematic review of published literatures to quantitatively analyze the prognostic value of Twist in NSCLC patients based on current evidence
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
