Abstract
Objective: Autoantibodies against signal recognition particle (SRP) were first found in the serum of a patient with polymyositis and were classified as myositis-specific antibodies. Myopathy associated with antibodies to SRP (anti-SRP myopathy) has recently been considered a type of immune-mediated necrotizing myopathy and is clinically characterized by severe muscle weakness, markedly elevated serum creatine kinase (CK) levels, and a poor response to corticosteroid therapy. However, the clinical characterization of anti-SRP myopathy may be not well established.
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