Abstract
BackgroundTo investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV).MethodsClinicopathological data of 53 cases of REAH were retrospectively analyzed. The immunoreactivity for CK 7, CK20, CEA, p53, and Ki-67, Alcian blue–periodic acid-Schiff (AB-PAS) staining and in situ hybridization for EBV-encoded RNA (EBER) were carried out.ResultsREAH lesions were covered with ciliated columnar epithelium and proliferation of subepithelial glands, which were positive for CK7, and negative for CK20, CEA, and p53. Goblet cell metaplasia was stained blue by AB-PAS. The frequency of EBER positive cases in REAH located in nasopharynx was 27.78%, compared with that in the nasal cavity (15.79%) and paranasal sinuses (12.50%), there were no statistical differences.ConclusionsREAH is an uncommon entity with distinctive morphologic features and EBV may have nothing to do with REAH.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/5875687401178748
Highlights
The term “hamartoma” was introduced by Albrecht in 1904 to distinguish between true neoplasms and tumorlike lesions [1]
In 1934, Goldsworthy applied this term to a benign tumor in the lung composed predominantly of a combination of fat and cartilage [2]. This term is used to designate a focal overgrowth of mature normal cells and tissues at sites of identical cellular composition; a hamartoma may occur in any organ
Hamartomas have been described as occurring throughout the body, they are rare in the upper aerodigestive tract [3]
Summary
The term “hamartoma” was introduced by Albrecht in 1904 to distinguish between true neoplasms and tumorlike lesions [1]. In 1934, Goldsworthy applied this term to a benign tumor in the lung composed predominantly of a combination of fat and cartilage [2]. This term is used to designate a focal overgrowth of mature normal cells and tissues at sites of identical cellular composition; a hamartoma may occur in any organ. It may arise from any of the germ layers and does not metastasize. To investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV)
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