Clinicopathological analysis of primary non-Hodgkin’s lymphoma of the female reproductive system

Abstract

Objective To retrospectively analyze the clinical pathological features and treatment outcomes of primary non-Hodgkin’slymphoma (NHL) of the female reproductive system. Methods A retrospective analysis was performed on the clinical data of 28 patients with primary NHL of the female reproductive system who were admitted to our hospital from 1990 to 2016. The lymphomas were classified and staged based on the WHO histological classification and the Ann Arbor staging system, respectively. Of the 28 patients, 18(64%) underwent surgery, 27(96%) received chemotherapy, and 8(29%) received radiotherapy. The Kaplan-Meier method was used to calculate survival rates. Results The 5-year follow-up rate was 86%.The median age was 56.5 years (13-80 years). The ovary was involved in 11 patients (39%). The lymphoma was staged as IVE in 18 patients (64%). The most common pathological type was diffuse large B-cell lymphoma. The median survival time was 23.5 months. The 1-, 3-, and 5-year overall survival rates were 89%, 74%, and 59%, respectively. Conclusions Primary NLH of the female reproductive system is an extremely rare neoplastic disorder with no typical clinical symptoms and mostly diagnosed in advanced stage. The combined treatment with surgery, chemotherapy, and radiotherapy plays an important role in the treatment of the disorder. Key words: Pelvic lymphoma; Female genital system; Non-Hodgkin lymphoma; Prognosis