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Abstract
Gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED), known also as AFP-producing carcinoma, is arare neoplasm. Ten cases with GAHED and 209 cases without GAHED were selected. Clinicopathological features ofGAHED were investigated. Thedisease-free survival (DFS) oftheGAHED group was compared with that ofthenon-GAHED group. Grossly, thetumours consisted oftwo early types and eight advanced types. Histologically, all tumours were composed ofvarious proportions oftubular, cribriform, papillary, solid, and/or trabecular growth patterns ofclear to slightly eosinophilic tumour cells. Hyaline globules were observed in all tumours. AFP and Hep-Par1 were immunoreactive in all tumours. In fluorescence in situ hybridisation ofHER2 gene/chromosome 17, theamplification ofHER2 gene was observed in two cases that showed positive reaction for HER2 protein. Clinical follow-up was available in nine cases. Regarding theclinical outcome, 3 and 6 patients were alive without disease and alive with disease, respectively. In astatistical analysis, theDFS oftheGAHED group was significantly worse than that ofthenon-GAHED group. GAHED is morphologically characterised by various growth patterns ofclear to slightly eosinophilic tumour cells and intracytoplasmic possession ofhyaline globules. This tumour may have thepotential to behave in anaggressive clinical fashion.
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