Abstract
Microinvasive carcinoma (MC) is thought to occur mostly in high-grade ductal carcinoma in situ (DCIS) associated with high tumor-infiltrating lymphocyte (TIL). We compared the nuclear grade (NG) of background DCIS and the degree of TIL (high or low) of MC and DCIS predominant-invasive carcinoma (invasion size 1 -5 mm) (DPI). Among total 2238 resected breast carcinomas (2007-2013), thirty-four (1.5%) MC and 47 (2.1%) DPI cases were identified. NG 1, 2 and 3 were seen in 24%, 32% and 44% of MCs and 25%, 32% and 43% of DPIs, respectively. With increasing NG, there was an increased tendency for TIL around in situ and invasive areas in MCs and in DPIs [NG1 (38% vs 8%), NG2 (36% vs 40%), NG3 (93% vs 85%), respectively]. However, the proportion of NG3 that were associated with high-TILs around invasive areas was significantly lower in DPIs (50%) than in MCs (94%) (p
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