Clinicopathologic study of 817 enucleations

Abstract

The clinical findings, the indications for enucleation and the histopathological diagnoses from 817 eyes from the University Eye Hospital in Leipzig, enucleated between 01/01/1980 and 31/12/1989 (433 males; 384 females), were analysed retrospectively to investigate, however, the therapeutic and diagnostic importance of enucleation to ophthalmological problems. The most frequent underlying ocular diseases were: intraocular tumour (47.7%), surgical disease [primary glaucoma, retinal detachment, cataract] (18.6%), trauma [enucleation within 4 weeks after the event] (10.3%), systemic disease (6.6%), inflammation (6.1%), other diseases (10.7%). The final causes for enucleation were: intraocular tumour (46.4%), secondary glaucoma (31.6%), atrophia and phthisis bulbi (11.9%), inflammation (6.5%), trauma (0.9%), other diseases (2.7%). An increase in the enucleation rate was noted with increasing age. The ophthalmoscopic diagnoses of 8 i.o. malignant melanomas and 7 cases of retinoblastoma were histopathologically not verified. The histopathological diagnoses included: exudative-hemorrhagic lesion (7), metastasis (1) respectively M. Coats (3), retinal detachment (2), M. Norrie (1), panophthalmitis (1). In 2 cases of i.o. malignant melanoma and 2 cases of retinoblastoma the tumours were clinically unsuspected. The incorrect clinical diagnoses included: secondary glaucoma (2) respectively M. Coats (1), secondary glaucoma (1).