Clinicopathologic Characteristics and Long-Term Outcome of Gastric Cancer Patients with Family History: Seven-Year Follow-Up Study for Korean Health Check-Up Subjects.

Jooyoung Lee,Joo Sung Kim,Yoo Min Han,Su Jin Chung,Ji Min Choi,Greger Lindberg

doi:10.1155/2020/4028136

Jooyoung Lee, Joo Sung Kim + Show 4 more

Open Access

https://doi.org/10.1155/2020/4028136

Copy DOI

Abstract

Methods This study was conducted on asymptomatic healthy individuals who underwent upper gastrointestinal endoscopy for the purpose of GC screening. Patients who were diagnosed with GC between October 2003 and December 2013 at Seoul National University Hospital Healthcare System Gangnam Center were identified. Demographic and clinicopathologic characteristics were compared between the groups with and without FHx of GC. Overall survival (OS) and recurrence-free survival (RFS) were assessed as primary outcomes. Results There were no significant differences in tumor characteristics according to FHx of GC. However, preexisting adenoma was more frequent in patients with FHx than in those without FHx (14.5% vs. 6.3%, p = 0.035). The proportion of patients with microsatellite instability (MSI) was also higher in groups with FHx of GC (43.2% vs. 13.2%, p = 0.006). Helicobacter pylori infection rates of patients with FHx of GC tended to be higher although not significant (70.5% vs. 61.3%, p = 0.188). However, OS and RFS at 5 years of the GC patients with FHx were not significantly different from those of patients without FHx. Conclusion Preexisting adenoma and GC with MSI are more common in patients with FHx of GC than in those without. There were no significant differences in the survival rate according to FHx.

Highlights

The incidence of gastric cancer (GC) has declined significantly worldwide over the past half-century and is possibly attributable to economic development, improved sanitation, and decreased Helicobacter pylori infection rates because of the expansion of eradication [1]
We investigated the clinicopathologic characteristics and long-term outcomes of GC according to the FHx of GC in a health screening cohort in a high-GCprevalence region of Korea
There were no significant differences in the tumor characteristics or overall prognosis between GC patients with and without FHx of GC

Summary

Introduction

The incidence of gastric cancer (GC) has declined significantly worldwide over the past half-century and is possibly attributable to economic development, improved sanitation, and decreased Helicobacter pylori infection rates because of the expansion of eradication [1]. Diagnosed GC cases were estimated at 1,034,000 in 2018, representing 5.7% of all newly diagnosed malignancies and accounting for 8.2% of cancer-related deaths [2]. Identifying risk factors for GC and managing high-risk individuals through active prevention and early detection strategies may be important in areas with high prevalence of GC, to reduce the socioeconomic burden caused by the disease. Environmental factors such as H. pylori infection, cigarette smoking, and excessive salt intake are known to be related to the development of GC [4, 5].

Objectives

Methods

Results

Conclusion