Abstract
Background This study was conducted to assess the risk of congenital giant nevus malignization. Material and methods We studied 8 cases of congenital nevi in patients aged 10 to 32 years, (5 men, 3 women). Nevi were located on the eyelid (1 case), scalp (3 cases), and back (4 cases). The tumor diameter ranged from 0.5 to 12 cm. The surgically excised tumors were fixed in 10% formaldehyde, paraffin-embedded, and stained with hematoxylin-eosin, van Gieson, and Fontana. Results The histological appearance was of junctional nevus, intradermal nevus and mixed nevus. Congenital melanocytic nevi showed some particular features: nevus cells frequently extended to the hypodermis, had a periadnexal location, and contained neuroid structures. The most common neuroid structures were composed of groups of cells resembling Wagner-Meissner corpuscles and Verocay body. In only one of our cases the giant congenital nevus underwent malignant change to malignant melanoma. Conclusions Congenital nevi are benign circumscribed tumors formed of nevus cells that penetrate into the deep dermis with the involvement of skin appendages. Giant congenital nevus is a potential precursor of malignant melanoma.
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