Clinicopathologic and Survival Characteristics of patients with squamous cell carcinoma and adenocarcinoma of uterine cervix in Yazd, Iran

Abstract

Introduction: Though the incidence of cervical squamous cell cancer (SCC) has reduced during recent years, the amount of cervical adenocarcinoma (AC) has propagated. There is a controversy over whether prognosis is better in SCC or AC. Similar studies have not been conducted in Iran. Material and methods: This is a descriptive-analytic study that is based on historical cohort method. In this retrospective work, all cases of cancer patients were studied from 2004 to 2015 and the medical records of all women recognized with cervical SCC and AC treated in Shahid Sadoughi teaching hospital and Shahid Ramesanzadeh Radiotherapy Center were recovered. In these patients, the epidemiologic characteristics, survival and the factors affecting the survival were investigated. Statistical analysis included frequency table and Chi-Square test. Patient survival was assessed using Kaplan- Meier assessments, and multivariate analysis was done by the Cox regression mode. Results: This study was done on 158 patients identified with cervical carcinoma. Their mean age at the time of diagnosis was 53.3987±1.02150 years. According to histopathologic types, 132 of the patients were classified as SCC with mean age of 52.4840±1.10612 years; while 26 patients were identified as AC with mean age of 58.0385±2.49830 years. The overall survival was 96.338±4.434 months (95% confidence interval) and it was 100.459±4.342 and 54.475±5.334 months for SCC and AC respectively. In the early and advanced stages, overall survival of patients with SCC was different (p=0.001). It was true about the patients with AC (p=0.002). Conclusion: The results of the current study showed the prognosis is worse in patients with cervical AC than cervical SCC