CLINICO-MORPHOLOGICAL FEATURES OF RE-CESAREAN SECTION

Abstract

A high number of repeat cesarean sections increases a risk of excessive bleeding, uterine atony, hysterectomy.The aim of study was to evaluate the efficacy of medical and technical methods (argon plasma coagulation, tranexamic acid, carbetocin) to prevent complications following repeat cesarean section and to improve the myometrial wound healing, to establish morphological features of uterine scar tissue in case of using argon plasma coagulation of myometrium in the area of the suture during the previous operation.Materials and methods Prospective cohort study of 87 patients who had undergone repeat cesarean section. I group included 42 women who had repeat cesarean section using argon plasma coagulation. Ten minutes before the operation, 1,0 g of tranexamic acid was injected intravenously. 100 mcg carbetocin was administered intravenously after cutting the umbilical cord. ІІ group comprised 45 women who had traditional cesarean section using Stark’s technique and Joel-Cohen incision. Pathomorphological study of scarred lower uterine segment myometrium was performed. Immunohistochemical staining against CD3, CD34, CD68, vimentin, α-SMA was performed.Results are presented as Mean±SD.Results. Total operative time was significantly shorter in the І group (37,7±2,4 minutes) compared to ІІ (47,4±1,6 minutes) (р<0,05). Volume of blood loss in the І group was 476,7±37,4 ml, and in the ІІ — 549,7±35,7 ml (p<0.05). Patients of the І group needed analgesic for 18-24 hours, the ІІ group — 36-72 hours after operation. The width of the uterine cavity in group І was 9,7±0,39 mm, in group ІІ — 14,8±0,52 mm (р<0,05). One patient of group І and 9 patients of group ІІ had signs of uterine subinvolution. Length of hospital stay after surgery in group I was 4,7±0,12 days, in ІІ — 6,8±0,24 days. The ultrasound thickness of myometrium in group I and group II is an average of 8,72±0,54 mm and 6,75±0,69 mm, respectively. Pathomorphological data of scarred lower uterine segment myometrium showed that in group I regenerative processes have more favorable course, a tendency to restore the structure of myometrium, while in group II there were processes of disturbed regeneration with the replacement of smooth muscle tissue varying maturity of connective tissue, moderate inflammatory process.Conclusion. So, the use of tranexamic acid, carbetocin and argon plasma coagulation is effective in reducing perioperative blood loss, total operative time, dosage of uterotonic and analgesic medications and postoperative hospital stay in patients giving birth by repeat cesarean section. According to the pathomorphological study, argon plasma coagulation of myometrium in the area of suture increases the value of the reparative processes and promotes the formation of a morphologically complete scar, with the predominance of smooth muscle cells over connective tissue.